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COVID-19-related Disruptions
April 03, 2020
Due to the current situation with COVID-19, we are operating with reduced staffing and there may be delays in responding to emails and phone calls at this time. In addition, because of institutional restrictions and uncertainty with courier services, the MMRRC is currently shipping or receiving live animals on a case-by-case basis. Please contact us to discuss your needs. For ongoing orders, we will continue to communicate frequently to keep you apprised of the status of your order. Thank you for understanding.
New MUMC Website!
The MU Metagenomics Center recently launched a new website – please visit us at:
http://mumc.missouri.edu
April 06, 2015
The MU Metagenomics Center recently launched a new website – please visit us at:
http://mumc.missouri.edu
Watch the video!
Microbiota Characterization
The gut microbiota (GM) is now recognized as a key factor in health and disease. Differences in the composition of the gut microbiota of research animals may contribute to altered phenotypes or poor reproducibility of animal-based studies. Culture-independent techniques such as next-generation sequencing (NGS) allow in-depth characterization of the gut microbiota. The MMRRC now offers a full line of NGS-related services including fecal DNA extraction, 16S rDNA gene sequencing, and informatics analysis to researchers using mouse models. For more information, please see here or contact mmrrc@missouri.edu.
Please visit
MU METAGENOMICS CENTER (MUMC)
April 02, 2015
Please visit
MU METAGENOMICS CENTER (MUMC)
Journal of the Missouri State Medical Association
June 01, 2013
SCIENCE OF MEDICINE
One Medicine: Collaborative Research on Human & Animal Disease for the Betterment of Both
Craig L. Franklin, DVM, PhD .......... 195
A Brief History of Animal Modeling
Aaron C. Ericsson, DVM, PhD, Marcus J. Crim, DVM & Craig L. Franklin, DVM, PhD .......... 201
New York Times Article Misleads on the Value of Mouse Models
Catherine E. Hagan, DVM, PhD .......... 206
The Mighty Mouse: The Impact of Rodents on Advances in Biomedical Research
Elizabeth C. Bryda, PhD .......... 207
The Laboratory Animal Veterinarian: More than just a Mouse Doctor
Cynthia G. Alvarado, DVM & Lonny M. Dixon, DVM .......... 223
Publications
Zhang C, Shi Y, Burch M, Olthoff B, Ericsson AC, Franklin CL. Transfer efficiency and impact on disease phenotype of differing methods of gut microbiota transfer. Sci Rep. 2022 Nov 15;12(1):19621. doi: 10.1038/s41598-022-24014-x. PMID: 36380056; PMCID: PMC9666633.
Gerb SA, Agca C, Stevey L, Agca Y. Effects of CO₂ Euthanasia of C57BL/6 Mice on Sperm Motility, In Vitro Fertilization, and Embryonic Developmental Competence. J Am Assoc Lab Anim Sci. 2022 Nov 1;61(6):603-610. doi: 10.30802/AALAS-JAALAS-22-000012. Epub 2022 Oct 25. PMID: 36283799; PMCID: PMC9732780.
Russell A, Copio JN, Shi Y, Kang S, Franklin CL, Ericsson AC. Reduced housing density improves statistical power of murine gut microbiota studies. Cell Rep. 2022 May 10;39(6):110783. doi: 10.1016/j.celrep.2022.110783. PMID: 35545042; PMCID: PMC9161176.
Amos-Landgraf J, Franklin C, Godfrey V, Grieder F, Grimsrud K, Korf I, Lutz C, Magnuson T, Mirochnitchenko O, Patel S, Reinholdt L, Lloyd KCK. The Mutant Mouse Resource and Research Center (MMRRC): the NIH-supported National Public Repository and Distribution Archive of Mutant Mouse Models in the USA. Mamm Genome. 2022 Mar;33(1):203-212. doi: 10.1007/s00335-021-09894-0. Epub 2021 Jul 27. PMID: 34313795; PMCID: PMC8314026.
Thurman CE, Klores MM, Wolfe AE, Poueymirou WT, Levee EM, Ericsson AC, Franklin CL, Reddyjarugu B. Effect of Housing Condition and Diet on the Gut Microbiota of Weanling Immunocompromised Mice. Comp Med. 2021 Dec 1;71(6):485-491. doi: 10.30802/AALAS-CM-21-000015. Epub 2021 Nov 15. PMID: 34782034; PMCID: PMC8718622.
Zhang C, Burch M, Wylie K, Herter B, Franklin CL, Ericsson AC. Characterization of the Eukaryotic Virome of Mice from Different Sources. Microorganisms. 2021 Sep 30;9(10):2064. doi: 10.3390/microorganisms9102064. PMID: 34683385; PMCID: PMC8538372.
Gerb SA, Dashek RJ, Ericsson AC, Griffin R, Franklin CL. The Effects of Ketamine on the Gut Microbiome on CD1 Mice. Comp Med. 2021 Aug 1;71(4):295-301. doi: 10.30802/AALAS-CM-20-000117. Epub 2021 Jul 23. PMID: 34301347; PMCID: PMC8383998.
Ericsson AC, Franklin CL. The gut microbiome of laboratory mice: considerations and best practices for translational research. Mamm Genome. 2021 Aug;32(4):239-250. doi: 10.1007/s00335-021-09863-7. Epub 2021 Mar 10. PMID: 33689000; PMCID: PMC8295156.
Ericsson AC, Hart ML, Kwan J, Lanoue L, Bower LR, Araiza R, Kent Lloyd KC, Franklin CL. Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism. Commun Biol. 2021 Jun 10;4(1):716. doi: 10.1038/s42003-021-02249-0. PMID: 34112927; PMCID: PMC8192786.
Norton CE, Grunz-Borgmann EA, Hart ML, Jones BW, Franklin CL, Boerman EM. Role of perivascular nerve and sensory neurotransmitter dysfunction in inflammatory bowel disease. Am J Physiol Heart Circ Physiol. 2021 May 1;320(5):H1887-H1902. doi: 10.1152/ajpheart.00037.2021. Epub 2021 Mar 12. PMID: 33710922; PMCID: PMC8163646.
Zhang C, Franklin CL, Ericsson AC. Consideration of Gut Microbiome in Murine Models of Diseases. Microorganisms. 2021 May 14;9(5):1062. doi: 10.3390/microorganisms9051062. PMID: 34068994; PMCID: PMC8156714.
Sigmon JS, Blanchard MW, Baric RS, Bell TA, Brennan J, Brockmann GA, Burks AW, Calabrese JM, Caron KM, Cheney RE, Ciavatta D, Conlon F, Darr DB, Faber J, Franklin C, Gersho TR, Gralinski L, Gu B, Gaines CH, Hagan RS, Heimsath EG, Heise MT, Hock P, Ideraabdullah F, Jennette JC, Kafri T, Kashfeen A, Kulis M, Kumar V, Linnertz C, Livraghi-Butrico A, Lloyd KCK, Lutz C, Lynch RM, Magnuson T, Matsushima GK, McMullan R, Miller DR, Mohlke KL, Moy SS, Murphy CEY, Najarian M, OBrien L, Palmer AA, Philpot BD, Randell SH, Reinholdt L, Ren Y, Rockwood S, Rogala AR, Saraswatula A, Sassetti CM, Schisler JC, Schoenrock SA, Shaw GD, Shorter JR, Smith CM, St Pierre CL, Tarantino LM, Threadgill DW, Valdar W, Vilen BJ, Wardwell K, Whitmire JK, Williams L, Zylka MJ, Ferris MT, McMillan L, Manuel de Villena FP. Content and Performance of the MiniMUGA Genotyping Array: A New Tool To Improve Rigor and Reproducibility in Mouse Research. Genetics. 2020 Dec;216(4):905-930. doi: 10.1534/genetics.120.303596. Epub 2020 Oct 16. PMID: 33067325; PMCID: PMC7768238.
Franklin CL, Ericsson AC. Complex Microbiota in Laboratory Rodents: Management Considerations. ILAR J. 2020 Oct 19;60(2):289-297. doi: 10.1093/ilar/ilaa011. PMID: 32706377; PMCID: PMC7583721.
Korte SW, Dorfmeyer RA, Franklin CL, Ericsson AC. Acute and long-term effects of antibiotics commonly used in laboratory animal medicine on the fecal microbiota. Vet Res. 2020 Sep 14;51(1):116. doi: 10.1186/s13567-020-00839-0. PMID: 32928304; PMCID: PMC7489021.
Agca Y, Agca C. Cryopreservation of Mouse Sperm for Genome Banking. Methods Mol Biol. 2021;2180:401-412. doi: 10.1007/978-1-0716-0783-1_17. PMID: 32797423.
Agca Y, Agca C. Cryopreservation and Transplantation of Laboratory Rodent Ovarian Tissue for Genome Banking and Biomedical Research. Methods Mol Biol. 2021;2180:469-483. doi: 10.1007/978-1-0716-0783-1_22. PMID: 32797428.
Badran M, Khalyfa A, Ericsson A, Gozal D. Fecal microbiota transplantation from mice exposed to chronic intermittent hypoxia elicits sleep disturbances in naïve mice. Exp Neurol. 2020 Dec;334:113439. doi: 10.1016/j.expneurol.2020.113439. Epub 2020 Aug 22. PMID: 32835671; PMCID: PMC7642108.
Wolfe AE, Moskowitz JE, Franklin CL, Wiemken TL, Ericsson AC. Interactions of Segmented Filamentous Bacteria (Candidatus Savagella) and bacterial drivers in colitis-associated colorectal cancer development. PLoS One. 2020 Jul 24;15(7):e0236595. doi: 10.1371/journal.pone.0236595. PMID: 32706816; PMCID: PMC7380633.
Moskowitz JE, Doran AG, Lei Z, Busi SB, Hart ML, Franklin CL, Sumner LW, Keane TM, Amos-Landgraf JM. Integration of genomics, metagenomics, and metabolomics to identify interplay between susceptibility alleles and microbiota in adenoma initiation. BMC Cancer. 2020 Jun 29;20(1):600. doi: 10.1186/s12885-020-07007-9. PMID: 32600361; PMCID: PMC7322931.
Wuri L, Agca C, Agca Y. Morphometric, subcellular, in vitro fertilisation and embryonic developmental assessment of mouse oocytes produced by anti-inhibin serum or pregnant mare serum gonadotrophin superovulation. Reprod Fertil Dev. 2020 Mar;32(5):474-483. doi: 10.1071/RD19131. PMID: 31972126; PMCID: PMC8020730.
Bains M, Laney C, Wolfe AE, Orr M, Waschek JA, Ericsson AC, Dorsam GP. Vasoactive Intestinal Peptide Deficiency Is Associated With Altered Gut Microbiota Communities in Male and Female C57BL/6 Mice. Front Microbiol. 2019 Dec 2;10:2689. doi: 10.3389/fmicb.2019.02689. PMID: 31849864; PMCID: PMC6900961.
Moskowitz JE, Andreatta F, Amos-Landgraf J. The gut microbiota modulates differential adenoma suppression by B6/J and B6/N genetic backgrounds in ApcMin mice. Mamm Genome. 2019 Oct;30(9-10):237-244. doi: 10.1007/s00335-019-09814-3. Epub 2019 Sep 23. PMID: 31549210; PMCID: PMC6842652.
Moskowitz J, Tracey L, Widmayer S, Dumont B. Meeting report: 32nd international mammalian genome conference. Mamm Genome. 2019 Apr;30(3-4):43-53. doi: 10.1007/s00335-019-09797-1. Epub 2019 Apr 1. PMID: 30937535; PMCID: PMC6494680.
Wuri L, Agca C, Agca Y. Euthanasia via CO2 inhalation causes premature cortical granule exocytosis in mouse oocytes and influences in vitro fertilization and embryo development. Mol Reprod Dev. 2019 Jul;86(7):825-834. doi: 10.1002/mrd.23167. Epub 2019 May 13. PMID: 31087431; PMCID: PMC7890572.
Bidot WA, Ericsson AC, Franklin CL. Effects of water decontamination methods and bedding material on the gut microbiota. PLoS One. 2018 Oct 25;13(10):e0198305. doi: 10.1371/journal.pone.0198305. PMID: 30359379; PMCID: PMC6201873.
Hart ML, Ericsson AC, Lloyd KCK, Grimsrud KN, Rogala AR, Godfrey VL, Nielsen JN, Franklin CL. Development of outbred CD1 mouse colonies with distinct standardized gut microbiota profiles for use in complex microbiota targeted studies. Sci Rep. 2018 Jul 4;8(1):10107. doi: 10.1038/s41598-018-28448-0. PMID: 29973630; PMCID: PMC6031694.
Korte SW, Franklin CL, Dorfmeyer RA, Ericsson AC. Effects of Fenbendazole-impregnated Feed and Topical Moxidectin during Quarantine on the Gut Microbiota of C57BL/6 Mice. J Am Assoc Lab Anim Sci. 2018 May 1;57(3):229-235. PMID: 29784074; PMCID: PMC5966229.
Montonye DR, Ericsson AC, Busi SB, Lutz C, Wardwell K, Franklin CL. Acclimation and Institutionalization of the Mouse Microbiota Following Transportation. Front Microbiol. 2018 May 28;9:1085. doi: 10.3389/fmicb.2018.01085. PMID: 29892276; PMCID: PMC5985407.
Ericsson AC, Gagliardi J, Bouhan D, Spollen WG, Givan SA, Franklin CL. The influence of caging, bedding, and diet on the composition of the microbiota in different regions of the mouse gut. Sci Rep. 2018 Mar 6;8(1):4065. doi: 10.1038/s41598-018-21986-7. PMID: 29511208; PMCID: PMC5840362.
Boynton FDD, Ericsson AC, Uchihashi M, Dunbar ML, Wilkinson JE. Doxycycline induces dysbiosis in female C57BL/6NCrl mice. BMC Res Notes. 2017 Nov 29;10(1):644. doi: 10.1186/s13104-017-2960-7. PMID: 29187243; PMCID: PMC5708113.
Ericsson AC, Montonye DR, Smith CR, Franklin CL. Modeling a Superorganism - Considerations Regarding the Use of "Dirty" Mice in Biomedical Research . Yale J Biol Med. 2017 Sep 25;90(3):361-371. PMID: 28955177; PMCID: PMC5612181.
Lee JR, Muckerman JE, Wright AM, Davis DJ, Childs TE, Gillespie CE, Vieira-Potter VJ, Booth FW, Ericsson AC, Will MJ. Sex determines effect of physical activity on diet preference: Association of striatal opioids and gut microbiota composition. Behav Brain Res. 2017 Sep 15;334:16-25. doi: 10.1016/j.bbr.2017.07.018. Epub 2017 Jul 23. PMID: 28743600; PMCID: PMC6326100.
Techasintana P, Ellis JS, Glascock J, Gubin MM, Ridenhour SE, Magee JD, Hart ML, Yao P, Zhou H, Whitney MS, Franklin CL, Martindale JL, Gorospe M, Davis WJ, Fox PL, Li X, Atasoy U. The RNA-Binding Protein HuR Posttranscriptionally Regulates IL-2 Homeostasis and CD4+ Th2 Differentiation. Immunohorizons. 2017 Aug 1;1(6):109-123. doi: 10.4049/immunohorizons.1700017. PMID: 30035254; PMCID: PMC6052877.
Brodeur AC, Roberts-Pilgrim AM, Thompson KL, Franklin CL, Phillips CL. Transforming growth factor-β1/Smad3-independent epithelial-mesenchymal transition in type I collagen glomerulopathy. Int J Nephrol Renovasc Dis. 2017 Aug 31;10:251-259. doi: 10.2147/IJNRD.S141393. PMID: 28919801; PMCID: PMC5587152.
Hart ML, Ericsson AC, Franklin CL. Differing Complex Microbiota Alter Disease Severity of the IL-10-/- Mouse Model of Inflammatory Bowel Disease. Front Microbiol. 2017 May 11;8:792. doi: 10.3389/fmicb.2017.00792. PMID: 28553262; PMCID: PMC5425584.
Khairallah MT, Astroski J, Custer SK, Androphy EJ, Franklin CL, Lorson CL. SMN deficiency negatively impacts red pulp macrophages and spleen development in mouse models of spinal muscular atrophy. Hum Mol Genet. 2017 Mar 1;26(5):932-941. doi: 10.1093/hmg/ddx008. PMID: 28062667; PMCID: PMC6075362.
Toth LA, Trammell RA, Liberati T, Verhulst S, Hart ML, Moskowitz JE, Franklin C. Influence of Chronic Exposure to Simulated Shift Work on Disease and Longevity in Disease-Prone Inbred Mice. Comp Med. 2017 Mar 1;67(2):116-126. PMID: 28381312; PMCID: PMC5402731.
Franklin CL, Ericsson AC. Microbiota and reproducibility of rodent models. Lab Anim (NY). 2017 Mar 22;46(4):114-122. doi: 10.1038/laban.1222. PMID: 28328896; PMCID: PMC5762113.
Ericsson AC, Personett AR, Turner G, Dorfmeyer RA, Franklin CL. Variable Colonization after Reciprocal Fecal Microbiota Transfer between Mice with Low and High Richness Microbiota. Front Microbiol. 2017 Feb 23;8:196. doi: 10.3389/fmicb.2017.00196. PMID: 28280484; PMCID: PMC5322181.